Mechanisms Underlying the Relationship between Sleep Problems and Drug Use in Adolescence

Duration: 2013 - 2019
Funding: NIH/NIDA
Principal Investigator: Diana Fishbein
Partners: University of California at Irvine, RTI, Brown University

Project image

Description

This prospective, longitudinal study was designed to elucidate mechanisms underlying the relationship between sleep ‎problems and propensity to drug/alcohol use in adolescents, from age 10 through 20. Our integrative, temporal model theorized that ‎sleep problems would be significant predictors of drug/alcohol initiation and escalation of use in adolescents. ‎

We proposed further that this relationship could be explained at least in part by emotion dysregulation, as ‎measured by tasks that recruit affective limbic structures and perturbations in neuroendocrine (cortisol) ‎functioning. Level of cognitive functioning would moderate the relationship between sleep problems and drug ‎use. Exposure to prolonged stress was expected to amplify the mediational relationship.

Finally, the model ‎predicted that eventual drug use would exacerbate sleep problems and lead to further decrements in sleep, ‎emotion regulation, and cognition, promoting an escalating pattern of use.

Project Team

Publications

Neurocognitive characteristics of early marijuana use initiation in adolescents: A signature mapping analysis

Fishbein, D., Novak, S. P., Ridenour, T. A., Thornburg, V., Hammond, J. C., & Brown, J. (2016). Neurocognitive characteristics of early marijuana use initiation in adolescents: A signature mapping analysis. Journal of Studies on Alcohol and Drugs, 77(3), 431-440. doi: 19371888